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KMID : 0043320210440100890
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Archives of Pharmacal Research
2021 Volume.44 No. 10 p.890 ~ p.901
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Mass spectrometry-based metabolomics in hair from current and former patients with methamphetamine use disorder
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Seo Min-Jae
Song Sang-Hoon
Kim Su-Ji
Jang Won-Jun
Jeong Chul-Ho
Lee Soo-Yeun
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Abstract
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Drug use disorder, a chronic and relapsing mentaldisorder, is primarily diagnosed via self-reports of drugseekingbehavioral and psychological conditions, accompaniedby psychiatric assessment. Therefore, the identifi cationof peripheral biomarkers that refl ect pathological changescaused by such disorders is essential for improving treatmentmonitoring. Hair possesses great potential as a metabolomicsample for monitoring chronic diseases. This study aimed toinvestigate metabolic alterations in hair to elucidate a suitabletreatment modality for methamphetamine (MA) use disorder.
Consequently, both targeted and untargeted metabolomicsanalyses were performed via mass spectrometry onhair samples obtained from current and former patients withMA use disorder. Healthy subjects (HS), current (CP), andformer (FP) patients with this disorder were selected basedon psychiatric diagnosis and screening the concentrations ofMA in hair. The drug abuse screening questionnaire scoresdid not diff erentiate between CP and FP. Moreover, accordingto both targeted and untargeted metabolomics, clusteringwas not observed among all three groups. Nevertheless,a model of partial least squares-discriminant analysis was established between HS and CP based on seven metabolitesderived from the targeted metabolomics results. Thus, thisstudy demonstrates the promising potential of hair metabolomesfor monitoring recovery from drug use disorders inclinical practice.
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KEYWORD
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Drug use disorder, Methamphetamine, Hair, metabolomes, Metabolomics, Mass spectrometry
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